Abstract

HERNANDEZ GONZALEZ, Erick Héctor; MOSQUERA BETANCOURT, Gretel; QUINTERO MARTINEZ, Osby  and  HERNANDEZ CABEZAS, Ileydis. Ewing´s sarcoma. AMC [online]. 2013, vol.17, n.5, pp. 623-640. ISSN 1025-0255.

Background: Ewing´s sarcoma is a highly malignant neoplasia that mainly affects children and adolescents. Around 95 % of these sarcomas appear between 5-25 years of age, are frequent in male sex and very infrequent in black people. Objective: to systematize and bring up to date the most useful information about the Ewing´s sarcoma for the clinical-surgical performance.  Method: a review of the literature from the last five years was conducted, making emphasis on epidemiology, histopathology, diagnosis, and treatment. Development: Ewing´s sarcoma presents an incidence of 2.73 cases per million per year in the general population. From the clinical point of view the symptoms can include pseudo-inflammatory problems characterized by a painful mass and pain with nighttime aggravations, along with fever, discomfort, and weight loss; these manifestations resemble an osteomyelitis. The diagnosis requires the application of immunohistochemistry techniques and molecular studies. The treatment has passed through a series of modalities: surgery, surgery and radiotherapy, radiotherapy and chemotherapy; nowadays, the surgery-chemotherapy association and eventually, the radiotherapy have been taken up again. Conclusions: histological heterogeneity favors the diversity of clinical ways of presentation and makes more complex its diagnosis. The close similarity to other diseases make of the Ewing´s sarcoma one of the tumors of most difficult treatment; that is why the early detection and the removal surgery fallowed by chemotherapy guarantee the best results.

Keywords : SARCOMA, EWING; BONE NEOPLASMS; BONE AND BONES; THERAPEUTICS; REVIEW LITERATURE AS TOPIC.

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