Introduction:

Ki67 is a regulatory protein of cellular cycle which is associated to the proliferation of tumoral cells. Its expression has always had an important role at the tumor classification and it is one of the prognostic and predictive factors in breast carcinoma.

Objective:

To determine the relationship between the expression of Ki67 and other classic prognostic factors used in breast cancer.

Methods:

A cross-sectional, analytic and descriptive study was carried out at the Teaching Clinic-Surgical Hospital Celestino Hernández, Villa Clara, from January 2017 to June 2019. It was included 286 women with diagnosis of infiltrating breast carcinoma, whose biopsies were studied by immunohistochemistry. The Ki-67 cell marker expression was categorized as low (Ki-67<20 %) and high (Ki-67>20 %). It was analyzed the relationship between level of expression of Ki67 and other classical prognostic and predictive factors.

Results:

The no special histological type (ductal carcinoma) was the type more often reported. High expression level of Ki67 was associated with the high histological grade (grade 3) and the overexpression of Her2. Low expression of Ki-67 (<20 %) was associated with the expression of estrogen and progesterone receptors. There was not significant association between the tumor size and the expression of Ki67.

Conclusions:

The levels of expression of Ki67 showed significant association with several predictive and prognostic factors of breast carcinoma.

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