Abstract

PADRON, Jorge A et al. Determination of the accumulated Fo during saturated steam sterilization cycles in a fermentor used for vaccine production. Vaccimonitor [online]. 2001, vol.10, n.2, pp. 1-6. ISSN 1025-0298.

Technical literature related to sterilization processes in industrial equipment was reviewed. The Fo concept was described and its application for evaluating the efficiency of the sterilization process in a fermentor. The temperature profile in different sections of the fermentor was studied during the sterilization cycles. After the application of some modifications, a reliable SAL was obtained in all sections of the fermentor.

Keywords : Sterilization process; validation; reactors.

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