Abstract

AASE, Audun. Opsonophagocytic activity against group b meningococci: An additional laboratory correlate of protection against meningococcal disease? . Vaccimonitor [online]. 2009, vol.18, n.2, pp. 84-86. ISSN 1025-0298.

Opsonophagocytic activity and serum bactericidal activity against group B meningococci were compared in sera from three vaccine groups given two different outer membrane vesicles vaccines separately or in combination. Opsonophagocytic activity defined more responders and revealed more cross-reactivity against heterologous strains than observed with serum bactericidal activity, and it showed the highest correlation with IgG-binding to live meningococci. Determination of opsonophagocytic activity may therefore be a valuable laboratory supplement to serum bactericidal activity for monitoring protection against group B meningococcal disease.

Keywords : Opsonophagocytic activity; correlate of protection; group B meningococci.

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