Abstract

CATELLANOS PUERTO, Edelis et al. Influence of Aloe vera L. on the immune humoral response of Balb/C mice immunized  against the hepatitis B virus. Rev Cubana Plant Med [online]. 2006, vol.11, n.3-4, pp. 0-0. ISSN 1028-4796.

A study was conducted by using the aqueous extract of Aloe vera L. to determine its immunogenic activity on Balb/C mice immunized with the recombinant vaccine against hepatitis B (Herbiovac HB) of national production. The latency, intensity, durability and the immunological memory were evaluated through extractions made at different times (3, 5, 27 weeks, 1 year and 15 days after the last 2 times). The sample obtained was processed by sandwich micro ELISA to quantify antibodies against the hepatitis B virus (anti HB). The control group and the group treated with Aloe were inoculated saline solution and injectable aqueous extract of Aloe B M by subcutaneous route, respectively, during 21 days. The results attained showed that all the seroconverted animals and had a hyperresponse. Elevation of the humoral response with presence of titers of protective antibodies was found after a year. The studies of pathological anatomy undertaken in the primary and secondary organisms of the immune response showed cellular proliferation in the thymus and increase of the area of B cells in the spleen.

Keywords : Adjuvant; hepatitis B; HBs Ag; Aloe vera..