Abstract

REMIGIO MONTERO, Antonia C.; VEGA HURTADO, Yamilé; PILOTO FERRER, Janet  and  RODRIGUEZ CHANFRAU, Jorge. Genotocixity of Justicia pectoralis Jacq. (tilo). Rev Cubana Plant Med [online]. 2008, vol.13, n.2, pp. 0-0. ISSN 1028-4796.

Objective: to detemine the genotoxic effect of the hydroalcoholic extract 30 % of aerial parts of Justicia pectoralis Jacq. (variety pectoralis) dried by spray drier. Methods: the Salmonella/microsomes with lines TA 1535, TA 1537, TA 98 and TA 100 with a concentration range from 50 to 5 000 ìg of powder/plaque (± S9) was used according to the protocol of incorporation in plaques; for the bone marrow micronucleus assay there were used Cenp mice: NMRI of both sexes that received isovolumetric doses (10 mL/kg) of 500, 1 000 y 2 000 mg of powder/kg by intragastric route at intervals of 24 h and were sacrificed 24 h after the last application. Results: no genotoxic effect was found with any of the strains in the assay of Salmonella/microsomes. The extract did not cause a statistically significant increase in the frequency of micronucleated polychromatic erythrocytes in the mice treated. No dose/positive response relation was observed. Conclusions: the powder did not reveal genotoxic effect under the experimental conditions of this study.

Keywords : Genotoxicity; bone marrow; micronuclei; Justicia pectoralis Jacq.; Salmonella/microsomes.