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Revista Información Científica
On-line version ISSN 1028-9933
Abstract
LEMUS-VALDES, Carmita and PADRON-ALBERTUS, Alejandro. The current therapeutic strategies in ovarian cancer treatment. Rev. inf. cient. [online]. 2023, vol.102 Epub July 21, 2023. ISSN 1028-9933.
Introduction:
Ovarian cancer is one of the most common and lethal tumor in women. This happens as a result of late-stage cancer detention and an increased chemoresistance to standard therapy. The current development in therapies to kill the cancer cells and its spread tendencies has emerged as a key alternative to treat tumors.
Objective:
To describe the current therapeutic strategies lead to confront different capabilities of tumor cells found in the ovarian cancer treatment.
Method:
A search of literuture was carried out in the following databases ScienceDirect, Redalyc, Latindex, ResearchGate, PubMed, Elsevier, ClinicalTrials.gov, SpringerLink, LARVOL's CLIN, Cuban Public Registry of Clinical Trials, from January to April 2023. A total of 50 text concerning ovarian cancer subject and alternative for treatment were selected. Development: The driving factors that promoted the use of ovarian cancer therapies were pointed out. The current therapeutic targets used in the treatment of this neoplasia were described, as well as the use of multiple approved drugs or in process of approval, including the synergistic drug combinations.
Final considerations:
There are a lot of options currently being implemented in ovarian cancer treatment. Despite clinical efficacy of targeted therapy, it´s presented still restricted to specific molecular subtypes and none of the assays illustrated survival benefit in general; the results obtained in the process of drugs development specifically targeting genome instability and sustained angiogenesis have been remarkable.
Keywords : ovarian cancer; epithelial ovarian cancer; antitumor drugs; chemoresistance; molecular targeted therapy; therapeutic strategy.