Abstract

BATISTA DUHARTE, Alexander et al. Effect of intranasal vaccine adjuvant AFCo1 on plasma concentration of theophylline in rats. MEDISAN [online]. 2012, vol.16, n.8, pp. 1284-1294. ISSN 1029-3019.

The effect of the adjuvant Finlay cochleate1 (AFCo1), applied intranasally 4 times in 2 dose levels (50 µg and 100 µg) on plasma concentration of theophylline administered 24 hours after the last application (5 mg/kg intraperitoneally) in Sprague-Dawley rats was evaluated in this study. Application subcutaneously of 2 doses of Freund's complete adjuvant (FCA) was used as positive control of inflammation. Rats receiving AFCo1 had no significant changes in serum theophylline concentration, while those treated with FCA developed local inflammation associated with signs of theophylline toxicity and increased specific G immunoglobulin, plasma concentrations and serum theophylline half-life as compared with the remaining groups. These results show that intranasal AFCo1-induced immunostimulation does not increase pharmacokinetic parameters and theophylline toxicity in the model used.

Keywords : AFCo1; adjuvant; Sprague-Dawley rat; P450 cytochrome; theophylline; toxicity.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )