Abstract

EXPOSITO LARA, Alexander; FERIA DIAZ, Gisela Eduarda; GONZALEZ BENITEZ, Sonia Noemí  and  MIGUEL SOCA, Pedro Enrique. Genetic variants of SARS-CoV-2 and its clinical implications. MEDISAN [online]. 2021, vol.25, n.6, pp. 1424-1446.  Epub Dec 08, 2021. ISSN 1029-3019.

The SARS-CoV-2, causal agent of the COVID-19 current pandemic, is suffering mutations as a consequence of its evolutive cycle, what has originated different genetic variants that have been grouped in two categories: worrying (alpha or British, beta or South African, gamma or Brazilian and delta or Indian) and of interest (lamdba, mu, epsilon, eta, iota, kappa, zed, theta); these categories bear clinical implications in the transmissibility, virulence and resistance from SARS-CoV-2 to the natural and acquired immunity, what represents a serious challenge in health services worldwide. These genetic variants are described in this work, with emphasis in its probable clinical impact, and the possibility that other variants could appear is also explained, as natural phenomenon in the evolution of viruses.

Keywords : coronavirus; SARS-CoV-2; COVID-19; mutation; viral pharmaco-resistence.

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