Abstract

GONZALEZ ESCUDERO, Mabel; PEREZ ACOSTA, Noel David  and  ROQUE PEREZ, Lázaro. DRESS syndrome secondary to allopurinol. Medicentro Electrónica [online]. 2020, vol.24, n.2, pp. 430-443.  Epub Apr 01, 2020. ISSN 1029-3043.

Drug hypersensitivity syndrome, also known as DRESS syndrome, is a severe pharmacodermia characterized by a polymorphous disseminated rash, fever, and multi-organ involvement. Its incidence ranges between 0.1 to 0.01% from the pharmacological exposures, with a probability of death ranging from 20 to 30%. It was first described in 1936 as an adverse reaction to phenytoin. Nowadays, it is known that it can also be associated with other drugs such as abacavir, metronidazole, doxycycline, isoniazid, carbamazepine, phenobarbital, beta-blockers, dapsone, ranitidine, nonsteroidal anti-inflammatory drugs and allopurinol. We present a 69-year-old male patient who developed a DRESS syndrome secondary to alupurinol. The patient showed unusual signs of this rare disease such as atypical lymphocytes, hepatomegaly and kidney disease; he dies shortly after from a septic shock due to Staphylococcus aureus.

Keywords : allopurinol/adverse effects; drug hypersensitivity syndrome.

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