Abstract

MOLINA MARTINEZ, José Luis et al. Preclinical and clinical aspects in the study of inflammatory periodontal disease and diabetes. Medicentro Electrónica [online]. 2021, vol.25, n.4, pp. 691-711.  Epub Oct 01, 2021. ISSN 1029-3043.

Biomedical research generates valuable scientific evidence to improve human disease treatment schemes. Chronic inflammatory periodontal disease affects the protective and supporting tissues of the teeth; it is one of the most prevalent chronic infections. Its etiology is multifactorial (bacteria are the primary factor). Dental plaque is a biofilm in which anaerobic microorganisms dominate; it can be divided into gingivitis and periodontitis. Gingivitis is an inflammatory state of the gums, without loss of periodontal attachment fibers or alveolar bone. Progressive destruction of collagen fibers and supporting bone structures occurs in periodontitis; it is related to different systemic complications, including diabetes mellitus (a metabolic disorder characterized by hyperglycemia). This review will allow specialists to investigate, on a preclinical scale, important aspects of these diseases in laboratory rodents.

Keywords : periodontal diseases; diabetes mellitus.

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