Abstract

MOLINA MARTINEZ, José Luis et al. High blood pressure in experimental animals. Medicentro Electrónica [online]. 2023, vol.27, n.1  Epub Jan 01, 2023. ISSN 1029-3043.

Medical and biological sciences require, as a priority, that research and experimentation be carried out on complete organisms (animal models). Its use has allowed the development of innumerable preclinical tests to evaluate pathogenic and therapeutic mechanisms of various diseases, as well as to study the causes, nature and cure of multiple human health disorders. In this work, we show a general overview of arterial hypertension biomodels where concepts, characteristics, origin, importance, utility and experimental procedures during their induction phase are described. The justification of the biomodels used in preclinical studies of this disease is also considered. Antecedents are also described to measure alterations, techniques and direct and indirect methods of measurement of arterial pressure, which was provoked experimentally in the laboratory animals to carry out the studies of human hypertension.

Keywords : animal experimentation; models, animal; hypertension; methods; arterial pressure; rattus; animals, laboratory; physiopathology.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )