Abstract

CUTIE ANIDO, Yudelkis et al. Thyrotropic Axis Role in Neurodegenerative Disorders. CCM [online]. 2013, vol.17, n.4, pp. 489-500. ISSN 1560-4381.

Thyroid hormones are primary regulators of intermediate metabolism in all body tissues. Particularly, they have very important functions at the level of nervous system, even having potentially neuro-protective effects. Usually, thyroid hormone levels are under a very close regulation in the nervous system and, because of that, small deviations from the normality range can be associated to neurodegenerative conditions. In this review, evidences about the roles of thyroid hormones in normal and pathological physiology of the nervous system are summarized, with an emphasis in neurodegenerative disorders and the molecular mechanisms involved. Findings suggest a significant role for thyroid hormones in several neurodegenerative diseases, although larger prospective studies are needed to clarify their function and to assess their usefulness as biomarkers and therapeutic targets.

Keywords : neurodegenerative disorders; thyroid function; thyroid hormones; hyperthyrodism; hypothyrodism; nervous system.

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