Abstract

NAVARRO DESPAIGNE, Daysi  and  LEDESMA OSORIO, Yusimit. Menopause, blood hypertension and hormone replacement therapy. Rev Cubana Endocrinol [online]. 2003, vol.14, n.1, pp. 0-0. ISSN 1561-2953.

To evaluate the influence of hormone replacement therapy on the climateric syndrome (CS) and the blood pressure values in postmenopausal women with hypertension, an open therapeutic assay was carried out, which included 45 non-obese women with slight/moderate hypertension. The course of the climateric symptoms and the blood pressure levels as well as the adverse effects of HRT were evaluated in every woman. The patients took Estradiol 2mg plus Levonorgestrel 1 mg per day for 12 months as drug therapy. During the application of the HRT, the climateric symptoms, particularly vasomotor (from 86,6 to 10%) and genitourinary (from 56,7 to 15%) decreased. All the women showed stable blood pressure levels. Five females needed to increase the hypertensive drug dose whereas the rest kept the same dose or reduced it. Reported adverse effects were vaginal bleeding, mastodynia, headache, vasculitis and ischemia found in the fifth toe. The last two patients had to cease treatment since the symptoms occurred on the sixth month of the treatment. We conclude that middle-aged women with blood hypertension benefit from HRT since it improves the climateric syndrome without worsening the blood pressure rates.

Keywords : POST MENOPAUSE [drug effects]; HORMONE REPLACEMENT THERAPY [methods]; HYPERTENSION; WOMEN; MIDDLE AGE..