Abstract

OCHOA TORRES, Francisco; KNIGHT BERMUDEZ, Hugh Gregorio  and  ALAVEZ MARTIN, Ernesto. Treatment of diffuse toxic goiter with 131I at doses of 80 µCi/g of thyroid tissue. Rev Cubana Endocrinol [online]. 2004, vol.15, n.3, pp. 0-0. ISSN 1561-2953.

131I has proved to be the most efficient therapeutics in the treatment of diffuse toxic goiter (DTG). However, there is no consensus on the dose to be administered: fixed dose or according to the functional activity of the thyroid and its size. In order to evaluate the therapeutical results at a dose of 80 Ci/g of thyroid tissue, estimated by palpation and without having into account the functional activity of thyroid and wether they had received propylthiouracil (PTU) previously , 61 patients diagnosed by the clinic, as well as determinations of TSH and total T4, were studied in individuals aged 20-80 of both sexes, with a thyroid size over 30 g. The posoperative follow-up was performed every 2 months for 3 years by the same specialist and with identical procedures. The efficiency of the treatment with the first dose was 85.2 %. The frequency of hypothyroidism at 3 years of evolution was 29.5. The age of the patient, the sex, the goiter size and the treatment with PTU did not influence on the response to it. The advantages showed by the method were: high efficiency, the dose of 131I may be easily calculated, simple application, decrease of the cost, since it is not necessary to assess the functional state of the gland, and reduction of visits.

Keywords : Diffuse toxic goiter; treatment..