Abstract

DIAZ SOCORRO, Cossette; TURCIOS TRISTA, Silvia Elena; ROBLES TORRES, Erick  and  GARCIA GARCIA, Yudit. Glucocorticoid deprivation syndrome. Rev Cubana Endocrinol [online]. 2014, vol.25, n.3, pp. 198-205. ISSN 1561-2953.

Glucocorticoid deprivation syndrome occurs in patients with endogenous hypercortisolism after surgery and in individuals receiving treatments at high doses of glucocorticoids for more than 2 weeks. The hypothalamus-hypophysis-adrenocortical axis regulates the daily cortisol secretion and presents a Circadian rhythm that may be affected by stress, disease or glucocorticoid administration The corticoid withdrawal may cause secondary adrenal insufficiency, corticoid deprivation or withdrawal syndrome and reactivation of the underlying disease for which they were prescribed. The secondary adrenal insufficiency is currently the most serious complication and the main reason for adrenal crisis and secondary adrenal insufficiency. The corticoid deprivation or withdrawal syndrome is self-limited and may be easily treated with temporary increase of the corticoid dose, followed by slow withdrawal of this agent. It is then necessary to find out the advantages and limitations of the glucocorticosteroid treatment and its gradual cessation. The state of the hypothalamus-hypophysis-adrenocortical axis should be adequately evaluated at the end of a long treatment, or with the use of supraphysiological doses of glucocorticoids.

Keywords : glucocorticoid deprivation syndrome; hyphothalamus-hyphophysis-adrecortical axis; glucocorticoids.

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