Abstract

SIERRA BENITEZ, Enrique Marcos; LEON PEREZ, Mairianny Quianella  and  MORALES FUENTES, Manuel Alejandro. Neurosurgical advances and molecular biology in the treatment of glioblastoma multiforme. Rev.Med.Electrón. [online]. 2019, vol.41, n.5, pp. 1230-1241.  Epub Oct 31, 2019. ISSN 1684-1824.

Despite advances in radiotherapy, chemotherapy and aggressive surgical resection treatments in glioblastoma multiforme, the prognosis remains discouraging. With the current review, the main alternatives for the treatment of glioblastoma multiforme are described in a current context. The authors reviewed the main articles published in English, in high impact journals worldwide, on the main advances in the treatment of this tumor. The main neurosurgical advances in the resection of glioblastoma were addressed, as well as the implications of tumor stem cells in the genesis and control of tumor proliferation, as well as the effect of hypoxia on tumor cell dynamics. DNA alterations causing tumor genesis and PTEN mutations in glioblastoma are also explained.

Keywords : glioblastoma multiple; molecular biology; surgical resection.

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