Abstract

GONZALEZ PEREZ, Elvis et al. Brain metabolism related to intravenous total anesthesia with ketamine hydrochloride for supratentorial tumors. Rev cuba anestesiol reanim [online]. 2009, vol.8, n.2, pp. 0-0. ISSN 1726-6718.

Introduction: Increasing consumption of oxygen and of cerebral blood flow, as well as of intracranial pressure, are adverse effects limiting the use of Ketamine hydrochloride in neurosurgical anesthesia; however, nowadays its use is reassessed because of its main principle is the neuroprotection. Material and Methods: Authors studied 40 patients operated on by craniotomy diagnosed with supratentorial tumors which had intravenous total anesthesia combined with Fentanyl and Ketamine hydrochloride to secure analgesia in each group. We registered the arterial carbon dioxide tension (PaCO2), oxygen jugular venous saturation (SvyO2), oxygen jugular arteriovenous difference (DavyO2), oxygen cerebral extraction (ECO2), and the cerebral metabolic rate (CMT). Results: The arterial tension of carbon dioxide fall progressively in both groups while there was a rise of oxygen jugular venous saturation during anesthetic procedure with a fall of oxygen jugular arteriovenous difference, oxygen cerebral extraction, and metabolic rate in the study groups without presence of significant differences in different study times (p < 0,05). Conclusions: Ketamine hydrochloride in analgesic doses may be used in a safe way in neurosurgical anesthesia for supratentorial tumors, without increase in cerebral metabolism.

Keywords : Ketamine; Propofol; Fentanyl; intravenous total anesthesia; neuroanesthesia; cerebral metabolism.

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