Abstract

ROSA DIAZ, Jorge  and  NAVARRETE ZUAZO, Víctor. Design of a strategy about midazolam infusion adjusted to the Greenblatt pharmacokinetic model. Rev cuba anestesiol reanim [online]. 2014, vol.13, n.3, pp. 220-230. ISSN 1726-6718.

Introduction: automated drug dispensing systems are research tools with a high impact on the practice of anesthesiology. Objective: present a methodology that enables the adjustment of estimations for the design of a manual dispensing regimen for midazolam based on a multicompartmental model. Method: an analytical pharmacokinetic simulation study was conducted using the parameters in the Greenblatt model. Error percentage, median performance error (MDPE) and estimation mean error (EME) were calculated for the analysis of results. Results: the Vd tpeak value estimated was 1302 ml / kg. The loading dose determined was 0.26 mg / kg. For the corrected mean value of CLc equals 32 ml / kg / min, the estimated Vinfi was adjusted according to the formula Vinfi = CpD x CL, whereas temporal variation was adjusted according to regimens Vinf (tn) = Vinf (tn-1) - [(Vinf (tn-1) x e(1 + 1/t)t)/100] and Vinf(tn) = Vinf (tn-1) x 0.85. Conclusions: a methodology was designed for manual TIVA administration of midazolam which yielded a minimum error with respect to the automated regime (TCI).

Keywords : intravenous anesthesia; manual TIVA; midazolam; Greenblatt.

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