Abstract

CASAS MARTINEZ, María de la Luz. Bioethical considerations on incentives for healthy volunteer participants in Phase I Research. Rev Hum Med [online]. 2023, vol.23, n.2  Epub July 12, 2023. ISSN 1727-8120.

Phase I Clinical Trials are conducted with the participation of healthy volunteers to test the safety and tolerability of pharmaceutical products. In them, participants are exposed to study drug risks without the possibility of direct medical benefit and usually must spend days or weeks at a research site. Incentives such as monetary payments are used to encourage enrollment and compensate participants for their time. These characteristics of Phase I healthy volunteer trials create a research context that differs markedly from most other clinical research, as most of them are financially vulnerable individuals. This paper aims to analyze bioethical factors that influence the granting of incentives to healthy volunteer participants in Phase I research.

Keywords : research; healthy volunteers; Phase I clinical trials; bioethics.

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