My SciELO
Services on Demand
Article
Indicators
- Cited by SciELO
Related links
- Similars in SciELO
Share
MediSur
On-line version ISSN 1727-897X
Abstract
ROMERO CABRERA, Ángel and AMORES HERNANDEZ, Leocadia. Oxi-Inflamm-Aging: a New Theory with Practical Implications. Medisur [online]. 2016, vol.14, n.5, pp. 591-599. ISSN 1727-897X.
Oxidative stress causes an impairment of the physiological systems essential for maintaining homeostasis, including the immune system. Immune dysregulation leads to a chronic low-grade inflammatory state in aging. This is the basis of the new integrative theory called oxy-inflamm-aging. The present article describes the foundations of this theory, the current research studies that support it, and its link with the pathogenesis of some age-related diseases. It is concluded that the adoption of a healthy lifestyle from an early age can contribute to a successful aging. The benefits of caloric restriction and antioxidant supplements are still under study in order to prevent oxidative stress and inflammation, and consequently achieve greater longevity and reduce the burden of age-associated diseases.
Keywords : aging; oxidative strees; inflammation; chronic disease; longevity.