Abstract

ROJAS RODRIGUEZ, Liana Yanet; HERRERA BATISTA, Aleida; RUIZ CANDINA, Héctor Juan  and  VALENTI PEREZ, Jaime. Folic acid effects upon histological characteristics of pancreas in alcoholic adolescent rabbits. Rev haban cienc méd [online]. 2013, vol.12, n.4, pp. 0-0. ISSN 1729-519X.

Introduction: hepatitis and pancreatitis are the most frequents complications of chronic alcoholism. Objective: the purpose of this paper was to determine the effect of folic acid on histological features of alcoholic pancreatitis in male adolescent rabbits. Material y Methods: twenty four adolescent rabbits divided into 4 groups were used: Group A (treated with ethanol), group B (treated with ethanol and folic acid) group C (treated with folic acid), group D (untreated controls). The experiment lasted 16 weeks. At that moment, fragments of pancreatic tissue of one centimeter were obtained for histological study. Results: group D present areas with ducts intra and interlobulars ducts with acidofilic and hialinic material between areas with normal ducts. There were planed epithelial cells in small ducts, instead of cubic cells; and in acinars cells it was found tumefaction signal. Groups B and C did not present alterations at all. Group treated with ethanol and folic acid presented appearance almost normal with few ducts with alteration. Conclusions: ethanol provoked histological features alterations on pancreas and it was avoided with acid folic treatment.

Keywords : alcoholism; adolescence; alcoholic pancreatitis; folic acid; rabbits.

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