Abstract

DE JESUS BATUN GARRIDO, José Antonio  and  SALAS MAGANA, Marisol. Leptin and rheumatoid arthritis, influence of this adipokine in the disease. Rev Cuba Reumatol [online]. 2016, vol.18, n.2, pp. 129-141. ISSN 1817-5996.

Abstract Rheumatoid arthritis is an inflammatory autoimmune disease which physiopathology both an environmental and genetic factors are involved, having as main cytokines involved the interleukin 1, interleukin 6 and tumor necrosis factor. Patients with rheumatoid arthritis have up to 2 - 3 times higher cardiovascular risk than the overall population, this risk is comparable to that of patients with diabetes mellitus. This increase in cardiovascular morbidity is explained by a higher prevalence of traditional risk factors, as well as non-traditional risk factors. Obesity or excessive fat tissue is a risk factor that can influence the increased cardiovascular risk, this due to poor metabolic regulation, increased blood pressure, dyslipidemia, free fatty acids circulating and cytokine production. Lately has emerged a broad interest in studying the relationship between rheumatoid arthritis and adipokines, however the results have been heterogeneous, due to the lack of homogeneity in the study groups. The aim of the following review is to talk about the influence of leptin in rheumatoid arthritis, in its pathophysiology, in the disease activity and in the increased cardiovascular risk.

Keywords : Rheumatoid arthritis; leptin; inflammation; cardiovascular risk.

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