Abstract

LA ROSA FABIAN, Christian Blas. The value of autoantibodies: from the theory to the clinical laboratory. Rev Cuba Reumatol [online]. 2018, vol.20, n.1, pp. 1-10. ISSN 1817-5996.  http://dx.doi.org/10.5281/zenodo.1173741.

Testing for autoantibodies is becoming more and more relevant, for diagnosing autoimmune disease. As a consequence, the detection of autoantibodies is increasingly recognized in classification criteria and diagnostic guidelines. It is important to know the presence of natural autoantibodies and the characteristics that allow their differentiation with pathological autoantibodies. Several special features of the autoantibodies and the development of new methodologies make the correct interpretation of the results of the antibody tests more and more difficult. In this article we review the characteristics of the autoantibody, its recognition as a heterogeneous analyte and its implication in the detection methods, as well as the utility in the clinical practice.

Keywords : autoantibodies; autoimmune diseases; immunological methods; clinical laboratory.

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