Abstract

VALDES DIAZ, Karen Cecilia et al. Lymphoproliferative disease associated with rheumatoid arthritis: report of three cases. Rev Cuba Reumatol [online]. 2019, vol.21, suppl.1  Epub Dec 01, 2019. ISSN 1817-5996.

Research in the last decade has shown that the risk of developing lymphoma in patients with rheumatoid arthritis is twice the risk of the general population. However, there is not data on the magnitude of this problem in Cuba.We present the cases of three patients with a diagnosis of seropositive rheumatoid arthritis treated with methotrexate who during their evolution developed non-Hodgkin's lymphoma.The patients received first-line chemotherapy and they achieved total remission with three-year survival so far.The diagnosis of lymphoproliferative diseases in patients with rheumatoid arthritis is a challenge; therefore, a high index of suspicion is necessary that, in the absence of reliable markers of lymphomagenesis, allows the timely management of these patients.

Keywords : rheumatoid arthritis; methotrexate; non-Hodgkin lymphoma.

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