Abstract

PINO FALCONI, Pablo Ernesto; MOYA ROMERO, Katherine Solange; RAMOS VEINTIMILLA, Wendy Yadira  and  GUEVARA ACURIO, Angela Lissette. Pathogenesis of rheumatoid arthritis, current therapeutic management and future prospects. Rev Cuba Reumatol [online]. 2021, vol.23, n.3  Epub Apr 01, 2022. ISSN 1817-5996.

Rheumatoid arthritis is a chronic systemic autoimmune disease that arises more frequently in women than in men, and is predominantly observed in the elderly. To present the result of a bibliographic review on general aspects related to the pathogenesis of rheumatoid arthritis and current therapeutic management, as well as future perspectives of new therapeutic approaches. There are two main subtypes of rheumatoid arthritis according to the presence or absence of anti-citrullinated protein antibodies. Citrullination is catalyzed by the calcium-dependent enzyme peptidylarginine deiminase, which changes a positively charged arginine to a polar but neutral citrulline as a result of post-translational modification. This work focuses on the anti-citrullinated protein antibodies -positive rheumatoid arthritis subset and divides the progression of the rheumatoid arthritis process into several stages. It should be mentioned that these stages can occur sequentially or simultaneously. A better understanding of how pathological mechanisms drive the deterioration of rheumatoid arthritis progression in individuals is urgently required in order to develop therapies that will effectively treat patients at each stage of disease progression.

Keywords : pathogenesis of rheumatoid arthritis; main subtypes; current therapeutic management; future perspectives.

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