Abstract

DOMINGUEZ FREIRE, Nervo David; ALBAN FIERRO, Pamela Elizabeth; FREIRE ONA, Ximena Consuelo  and  NUNEZ LOPEZ, Jenniffer Katherine. Perspectives with targets for the treatment of rheumatoid arthritis. Rev Cuba Reumatol [online]. 2022, vol.24, n.2  Epub Oct 01, 2022. ISSN 1817-5996.

Rheumatoid arthritis is classified as a systemic polyarticular chronic autoimmune joint disease that mainly affects the hands and feet. The objective of this work is to show published information that contributes to directing the management of RA with new drugs. Epigenetic modifications can regulate gene expression without altering the DNA sequence. Regulation of non-coding RNAs (ncRNAs), DNA methylation, RNA methylation, and histone modifications are considered the main mechanisms of epigenetic regulations. Numerous investigations have established that various abnormalities in these mechanisms lead to the development of RA. This work summarizes new targets, including proteins, small molecular metabolites and regulators of epigenetics. They are promising molecular targets for drug discovery to alleviate disease onset and resolve non-response and partial responses, as well as adverse effects of current DMARDs. It is undeniable that further efforts are still needed to further define the underlying signaling pathways affected by these newly discovered molecules and to develop appropriate therapy methods.

Keywords : rheumatoid arthritis; perspectives with targets; new drugs; epigenetics.

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