Abstract

GIL DEL VALLE, Lizette; RABIERO MARTINEZ, Carlos Luis  and  WEISER, Mark. Interplay among oxidative stress, genetic and epigenetic events in human biological processes: A possible bases of medical ozone mechanism of action. Rev. CENIC Cienc. Biol [online]. 2020, vol.51, n.1, pp. 35-47.  Epub Apr 01, 2020. ISSN 2221-2450.

Reactive oxygen species (ROS) can act as damaging molecules, but also represent central hubs in cellular signalling networks. Increasing evidence indicates that ROS increase perform an important role in the pathogenesis of diverse diseases degenerative and pathogen mediated although the underlying mechanisms and consequences of pathophysiology elevated ROS in most of them are still not completely resolved. The search was carried in the LILACS, PAHO, SciELO, EMBASE, PubMed and Infomed databases, by Google search engines and Google Scholar where the key words were placed and permit identification of original articles, theses, other articles of bibliographic review and high citation index journals published from 1950 to 2019, in Spanish or English. Two hundred thirty documents were identified, of which 58 were selected. The most important oxidants and reactive oxygen species produced by various physiological pathways, chemical and biological factors, including genetic and pathological conditions have been revised. More recently, alterations of the epigenetic landscape, which can affect DNA methylation, post-translational histone modifications, ATP-dependent alterations to chromatin and non-coding RNA transcripts, have been considered to be of increasing importance in the pathogenesis of most of diseases and aging. Different authors showed that epigenetic changes are highly dynamic and reversible. Thus, they might provide an important link between the actions of ROS, epigenetic and diseases. Ozonetherapy used by diverse application ways supports its pharmacological effect in different oxidative stress-associated diseases. Some authors recognized ozone interaction with diverse components in biological environment mediate formation of peroxides and aldehydes that activate different pathways as Nrf2 and NF-kB axes influencing also epigenetic signatures. As result, dose concept in ozone therapy and it hormetic response has a crucial role to manage the equilibrium inflammation / pro-inflammation responds. This review will provide an overview of the role of ROS in modulating the epigenetic landscape in the context of physiology but also link of redox state and disease and ozonetherapy biological effects.

Keywords : Platelet Rich Plasma; Inflammation; Ozone; HIV; Lipodystrophy.

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