Introduction:

the majority of breast carcinomas subtype are positive to the expression of hormone receptors which is associated to a good response to the endocrine therapy.

Objective:

to determine the incidence of the luminal subtypes luminal A diagnosed at the Teaching University Hospital Celestino Hernández, Villa Clara and its correlation with classical prognostic value clinic-pathological variables.

Methods:

a retrospective, cross-sectional study was carried out at the Hospital Celestino Hernández of the period from January 2017 to June 2019. The research included 281 women with diagnosis of infiltrating breast carcinoma, whose biopsies were studied by immunohistochemistry. It was determined the incidence of the luminal subtypes luminal A and B and their correlation with the variables: age, location, tumor size, histologic type and histologic grade. The proliferation index was determined for luminal B tumors.

Results:

the molecular subtype luminal B had a higher incidence. In both luminal subtypes more than two third of patients were older than 50 years old, more than 60 % had no special histology tumors and similar percentage were associated to moderately histological types of breast carcinoma. The poorly-differentiated tumoral lesions and the tumor size larger than 2 cm was reported with higher incidence in luminal B tumors and more than 90 % of tumors of that molecular subtype had a high proliferation index.

Conclusions:

the molecular subtype luminal B had clinic and histological features that render a more aggressive biological behavior.

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