Abstract

MARTINEZ GONZALEZ, Luis Raúl; VALLADARES HERNANDEZ, Marta  and  PEREZ MARTINEZ, Caridad. Indomethacin therapy in the treatment of hydramnios. Rev Cubana Obstet Ginecol [online]. 1998, vol.24, n.3, pp. 133-136. ISSN 1561-3062.

An study was made on 8 pregnant women having hydramnios, four of them having symptoms of risk for pre-term delivery, or light dyspnea, who were treated with oral indomethacin (100 mg/d) for 7 days in three cycles). The interval between the diagnosis and the beginning of therapy was 27 ± 3 weeks. Fetal biometry was made weekly, as well as echocardiography, to analyze the ductus constriction, and there was no evidence that this happened in those cases under treatment. The 8 cases showed that 62.5 % was born after 37 weeks of pregnancy, with low weight (37.5 %) and 1 of them had retarded intrauterine growth. The index was normalized between 50 and 95 percentage in 6 of the cases after the third cycle of treatment. A series-study of fetal bladder was carried out by echographia before and after indomethacin therapy, showing a significant decline of fetal diuresis. In 3 of 8 cases, the cause of hydramnios was detected. It occured a gemellary´s death and a neonatal death too. It is recommended to use this indomethacin therapy for hydramnios, following up strictly the parameters involved in the evolution.

Keywords : POLYHYDRAMNIOS [drug therapy]; INDOMETHACIN [administration & dosage]; INDOMETHACIN [therapeutic use].

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )