Abstract

VEGA CONEJO, Viviana; VINAS PORTILLA, Carlos I.; LANTIGUA CRUZ, Aracely  and  DEL MONTE SOTOLONGO, Elena. Chromosome defects and reproductive failures: A study of 452 patients. Rev Cubana Obstet Ginecol [online]. 1999, vol.25, n.1, pp. 19-23. ISSN 1561-3062.

The results of the chromosomal studies conducted among 452 patients who were referred to the Cytogenetics Laboratory of the National Center of Medical Genetics due to reproductive failures are analyzed in this paper. These individuals were classified into 7 groups according to the indication. The lymphocyte culture technique was used to obtain the karyotype. 13 chromosome aberrations were found for a frequency of 2.9 %. There were 5 cases with mosaics of the X chromosome (1.11 %), 4 with Robertsonian translocations (0.88 %), 2 with balanced translocations (0.44 %), and 2 with mosaics of nonidentified markers (0.44 %). Results are discussed in connection with the criteria used for indicating these studies and with literature reports.

Keywords : ABORTION, HABITUAL [genetics]; INFERTILITY [genetics]; CHROMOSOME ABNORMALITIES; CHROMOSOME ABERRATIONS; TRANSLOCATION (GENETICS).

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