Abstract

REYES LLERENA, Gil A et al. Analytical study and subject matter updating of a Cuban group of patients presenting with Lupus and pregnancy. Rev Cubana Obstet Ginecol [online]. 2009, vol.35, n.4, pp. 58-74. ISSN 1561-3062.

OBJECTIVES: to know the clinical and epidemiological behavior of the pregnant patients presenting with systemic lupus erythematosus (SLE), the maternal-fetal outcome, and the therapeutical approach presently proposed. To analyze the factor frequency e.g. lupus anticoagulant and other clinical manifestations associated with secondary antiphospholipid syndrome complicating the lupus course and the fetus. METHODS: a analytical, observational and ambispective study of 160 patients diagnosed with SLE, seen or admitted in National Service of Rheumatology (NSR) and in CIMEQ from January, 1985 and February, 2009. Statistical analysis was made using the relative frequencies and percentages from a Excel database. Significance level was established in p<0,05. RESULTS: there were 385 pregnancies with a ratio of 2,40 pregnancies/ patient I, life birth and healthy 313 (81,29 %); 72 (18,71 %) losses of pregnancy including 14 abortions (16,6 %). There were preterm labors in 22 patients (13,7%), high blood pressure associated to pregnancy in 18 (11,25 %), and preeclampsia in 12 (7,53 %). We confirmed clinical manifestations of lupus-associated antiphospholipid syndrome in 10 % of pregnants.] CONCLUSIONS: fertility was not compromised; it is a high risk pregnancy and is frequent the occurrence of mother disease outbreaks, spontaneous abortions, preterm labors and possibility of dead fetus. We considered that it is valuable information for the multidisciplinary staff facing the challenge to achieve the care of pregnants presenting SLE.

Keywords : Lupus; outcome; activity levels; maternal-fetal mortality.

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