Abstract

NODARSE RODRIGUEZ, Alfredo et al. Second trimester echographic markers as chromosome-diseases risk indicators. Rev Cubana Obstet Ginecol [online]. 2009, vol.35, n.4, pp. 85-98. ISSN 1561-3062.

Second trimester echographic markers have revolutionize the risk estimation for chromosome diseases, allowing to identify an increase risk in pregnants. OBJECTIVES: to carry out a preliminary assessment of second trimester echographic markers like risk indicators for chromosome diseases in patients with a cytogenetics prenatal diagnosis. METHODS: a cross-sectional, descriptive and retrospective study was conducted to make a preliminary assessment on markers usefulness. In this assessment all clinical records of pregnants with cytogenetics study were reviewed in Provincial Genetics Department of Havana City from "Ramón González Coro": Gynecology and Obstetrics Hospital between January, 2006 and December, 2007. From that total, 230 pregnants seen in this consultation were studied to assess the second trimester echographic markers more frequent like risk indicators of chromosome diseases, were the study sample. RESULTS: from the 15 patients presenting with chromosome diseases, only one had negative markers, showing a relation between positive markers and diagnosis of chromosomal aberrations. Markers with a better predictive value were Cystic Hygroma, IUGR and a increased nuchal fold. CONCLUSIONS: when there are not second trimester positive echographic markers, it allows confirm with a 90% of probability that fetus has not chromosomal alteration.

Keywords : Echographic markers; prenatal diagnosis; chromosomal alteration; nuchal fold.

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