Abstract

CANCIANO CHIRINO, Ernesto; LOPEZ SILVERIO, Reina María; ALFONSO GUERRA, Annia  and  RIO PONCIANO, Orlando. Pregnancy-associated migraine, epidemiology, therapy and clinical course in a Cuban population. Rev Cubana Obstet Ginecol [online]. 2011, vol.37, n.3, pp. 312-319. ISSN 0138-600X.

INTRODUCTION: Migraine is the more frequent neurological disease associated with pregnancy, the 20 % of fertile women with difficult pharmacologic management and a low level of national evidences. OBJECTIVES: The aim of present research is to characterize the variables able to influence on the clinical course of migrainous pregnants from January, 2006 to December, 2009 in a clinical/obstetric consultation of the San Antonio de los Baños regional, Artemisa province, Cuba. Authors identified age, headache intensity and gestational time, frequency according to migraine variety, pharmacological therapy used and the dose, also, other diseases associated with pregnancy were evaluated. METHODS: A randomized prospective and descriptive study was coneucted in 240 pregnants with one or more headache crises who meet the diagnostic criteria of migraine according to the International Headache Society. RESULTS: The global mean was of 23.75 years, with a trend to decrease according to the normality analysis. In puerperium such crises were more frequent and intense (50.4 %), with a frank statistical association among variables. The was predominance of migraine with aura (ratio 2/1) in a greater relation to crises frequency (74.5 %) demonstrated by means of Chi² (p < 0.05, 95 % CI), the paracetamol was the more used drug at high dosis (66.1 %). Arterial hypertension was the more frequent pathology (25.8 %) with a attributable high risk (18 x 1000). CONCLUSION: Although it not influence significantly in the final course of pregnancy, migraine is present early in life with a difficult therapeutical control depending on variety and frequency, able to increase the vascular risk in a near future.

Keywords : Pregnancy; migraine; therapeutics; clinics; epidemiology.

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