Abstract

LEON CRUZ, Grettell et al. Cellular immune response in patients presenting with benign and malignant lesions of cervix. Rev Cubana Obstet Ginecol [online]. 2011, vol.37, n.4, pp. 524-532. ISSN 0138-600X.

Objective: To study the immunologic parameters in patients presenting with intraepithelial lesions (IEL) and carcinoma in situ of cervix in the National Institute of Oncology and Radiotherapy over 2009. Methods: A study was conducted in 20 patients to determine the immuno-phenotypical of lymphocytes in peripheral blood by flow-cytometry and the functional ability in face of diverse mitogen using the AND synthesis method. The correlation analysis among the immunologic and epidemiologic variables was carried out by an estimation of Pearson's correlation coefficient. For the statistic test the SPSS statistical package was used (version 11.5). Results: The subgroup of Tc + CD8 lymphocytes showed higher values statistically significant ( p= 0.004) only for patients presenting with IEL. In all patients, independently of disease stage and of the mitogen used, the stimulation rates (SR) were lower than the values of controls. Conclusions: The alterations in the immune system in patients with cervix pathology are associated with the progress of lesions.

Keywords : Cervical intraepithelial neoplasm (CIN); carcinoma in situ; immuno-phenotype; AND synthesis.

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