Abstract

GOMEZ-GUTIERREZ, Alejandra María; PARRA-SOSA, Beatriz Elena  and  CESAR BUENO-SANCHEZ, Julio. Function of Receptor 1 in uptaking transferrin and its relation to iron deficiency and iron gestational preeclampsia. Rev Cubana Obstet Ginecol [online]. 2013, vol.39, n.1, pp. 33-42. ISSN 0138-600X.

Iron deficiency gestational anemia affects 48 % of women and it is associated with deleterious effects for the mother and her fetus. For mother iron uptake, the syncytiotrophoblast expression of glycoprotein transferrin receptor 1 (TfR1) is required. In cellular trails, in animal models and in humans, iron deprivation has been associated with an increase in TfR1 transcription and expression, which has been explained as a compensatory mechanism for the fetus iron uptake. On the other hand, pregnancy alterations such as preeclampsia are expected to increase in the expression of placental TfR1; however, a reduction of it has shown. This event has been explained as a type transcriptional regulatory factor related to the hypoxia-inducible transcription. Our objective was to review evidence to support that in the reduction of TfR1 preeclampsia expression, changes in glycosylation are involved as a posttranslational modification regarding the appropriate folding, maturation and receptor export to the cell membrane. PubMed database was consulted to identify the most relevant articles. The descriptors used were iron metabolism, anemia, placenta, transferrin receiver, preeclampsia, glycosylation. A posttranscriptional regulation related to glycosylation is proposed explaining how a reduction in expression is generated, despite of the increase in RNA expression of TfR1messenger induced by hypoxia in the preeclamptic placenta.

Keywords : iron metabolism; iron deficiency; placenta; transferrin receptor; preeclampsia; N-glycosylation.

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