Abstract

TABOADA LUGO, Noel. The Notch Signaling Pathway at the Origin of Some Congenital Malformations. Rev Cubana Obstet Ginecol [online]. 2018, vol.44, n.3, pp. 1-17. ISSN 1561-3062.

Notch signaling pathway plays a key role to regulate cell grow, fates, proliferation and programmed cell death in development of eukaryotic organisms. This pathway is related with an enormous diversity of developmental processes and its dysfunction is implicated in the origin of many congenital malformations. A review was performed to provide updated information on Notch signaling pathway involved in the origin of some congenital malformations related with maternal deficiency of folic acid and other micronutrients. Published medical literature in Spanish and English languages was retrieved from PubMed, Medline, Scielo, Lilacs and the Cochrane Library in January 2018, using appropriate key words. Knowledge about this signaling pathway could help to better understand some topics of morphogenesis, since by acting as a master controller of cell fate, proliferation, differentiation and programmed cell death, it offers susceptible and specific points which make possible to prevent some human congenital malformations

Keywords : signaling pathways; Notch signaling pathway; epigenetics mechanisms; congenital malformations; congenital heart diseases; harelips, neural tube defects.

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