Abstract

FERNANDEZ ENRIQUE, Kenia et al. Use of diafiltration in the lavage of cultures of Leptospira interrogans canicola canicola for the production of vaccine vax-SPIRAL. Rev Cubana Med Trop [online]. 2005, vol.57, n.1, pp. 69-70. ISSN 1561-3054.

It was proposed to substitute the present technology of the lavage operation for a tangential microfiltration system at the lavage stages of the culture of Leptospira interrogans canicola canicola. It was proved that this system may be applied, since no cellular affectation was observed and high pollutant elimination levels were obtained.

Keywords : Vax-SPIRAL; leptospirosis; diafiltration.

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