Abstract

BENITEZ ZAMORA, José Daniel et al. Scale-up of the fermentation of Leptospira interrogans canicola canicola for the production of vax-SPIRAL vaccine. Rev Cubana Med Trop [online]. 2005, vol.57, n.1, pp. 71-72. ISSN 1561-3054.

The operational conditions for the production of vaccine vax-SPIRAL were established at the scale of 100 L. It was concluded that it should be carried out with an air flow of 10 L/min (0.1 vvm) and without mechanical agitation.

Keywords : Vax-SPIRAL; fermentation; leptospirosis.

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