Abstract

ROMAY PENABAD, Cheyla. Capacidad antioxidante total del suero en la diabetes mellitus. Rev Cubana Invest Bioméd [online]. 1996, vol.15, n.2, pp. 0-0. ISSN 1561-3011.

With the aim of evaluating the presence of oxidative stress in diabetes mellitus, it was studied in a group of 89 healthy subjects and 104 diabetic patients (50, type I and 54, type II) the variation of total antioxidant capacity of serum (TRAP) in connection with the glicemic control degree, evaluated by the value of serum fructosamine. A marked reduction of TRAP capacity was found in the group of poorly controlled patients (fructosamine ³ 3,5 mol/L) as regards the controls and the successfully controlled patients. Of the antioxidative parameters of serum contributing to TRAP value, only the uric acid seems to be responsible of its signficant decrease among the poorly controlled patients. These results provide elements about the presence of oxidative stress in diabetes and about the possibility of using an antioxidative nutritional therapy in this disease.

Keywords : REACTIVE OXYGEN SPECIES; DIABETES MELLITUS, INSULIN DEPENDENT [blood]; NON-INSULIN DEPENDENT [blood]; FREE RADICALS; OXIDATIVE STRESS; ASCORBIC ACID [blood]; VITAMIN E [blood]; URIC ACID [blood]; FRUCTOSE [blood].