Abstract

BROCHE VALLE, Félix et al. Bases moleculares de la hipertrofia ventricular izquierda: papel del estrés oxidativo. Rev Cubana Invest Bioméd [online]. 1997, vol.16, n.2, pp. 83-92. ISSN 1561-3011.

Arterial hypertension (AHT) as a primary disease is one of the first causes of morbidity and general mortality in many countries. Ischemic cardiopathy and other clinical forms of the atherosclerotic cardiovascular disease are more common among hypertensives. The appearance and severity of the manifestations of myocardial infarction increase if left ventricular hypertrophy coexists. In the hypertrophic myocardium, events of ischemia/reperfusion take place during each cardiac cycle. Under these conditions, different factors lead to the oxidative stress, whose consequences are expressed by morph ofunctional alterations of the heart and other systems. In this paper, the main mechanisms giving molecular bases of ventricular hypertrophy ahod of the arterial wall in hypertensives, as well as the origin and physiopathologic significance of the oxidative stress in this disease, are presented aimed at contributing to the theoretical support of the criteria for diagnosis, prognosis, evolution and treatment of the hypertensive patient suffering from left ventricular hypertrophy.

Keywords : HYPERTROPHY; LEFT VENTRICULAR [physiopathology]; HYPERTENSION [complications].