Abstract

FERNANDEZ-BRITTO RODRIGUEZ, José E et al. Aterosclerosis, colesterol y pared arterial: algunas reflexiones. Rev Cubana Invest Bioméd [online]. 1999, vol.18, n.3, pp. 169-175. ISSN 1561-3011.

The studies linking cholesterol to the development of atherosclerosis date back to the 1950s. The cardiovascular risk factors such as hypertension, diabetes mellitus, smoking and obesity, among others, have proved to have a strong association with cholesterol. In this paper the present basic elements of the physiopathology of atherosclerosis related to cholesterol and to the arterial wall are approached. The physiopathology of the low density lipoproteins cholesterol (LDL-c), the factors influencing on its concentration among the fluids of the intima and the extravascular fluids, the role of the modified LDL-c in the vascular intima, the contribution of Lp(a) to the development of atherosclerosis, as well as the participation of high density lipoproteins quit on cholesterol (HDL-c) and its reverse transport as a mechanism opposing to the atherosclerotic process are also included.

Keywords : ATHEROSCLEROSIS [physiopathology]; LIPOPROTEINS, HDL CHOLESTEROL [physiology]; LIPOPROTEINS, LDL CHOLESTEROL [physiology]; RISK FACTORS..

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