Abstract

ANIAS CALDERON, José M  and  OSA PALACIO, Jorge Luis de la. Dosis óptimas para la inducción del bostezo con apomorfina en el humano sano. Rev Cubana Invest Bioméd [online]. 1999, vol.18, n.3, pp. 208-214. ISSN 1561-3011.

The effect of the subcutaneous administration of 4, 6, 8, 10, 12, 14 ?g of apomorphine in 16 volunteer sound individuals was studied aimed at finding the optimal dose for the induction of yawning in the healthy human. The subjects were divided into 2 subgroups of 8 to give cach of them only 3 doses. They were administered physiological saline to study the spontaneous yawning (control situation). The results show that the range from 8 to 10 ?g is the most suitable for the induction of yawning. The lower doses had little inducing effect, whereas higher doses produced undesirable effects.

Keywords : APOMORPHINE [administration & dosage]; YAWNING [drug effects].

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