Abstract

ALMEIDA, Ricardo; GONZALEZ RAMIREZ, Gisela; GONZALEZ GRIEGO, Antonio  and  RAMIREZ ALBAJES, Victoria. Durabilidad de la respuesta inmune contra el vhb en niños de un círculo infantil en Cuba. Rev Cubana Invest Bioméd [online]. 2000, vol.19, n.1, pp. 76-90. ISSN 1561-3011.

The Ministry of Public Health of Cuba sets out to wipe out viral hepatitis B for the year 2000. To attain this goal, it implemented a National Program which started in 1991 with the immunization of children from Hepatitis B carrier mothers and was extended to all neonates from 1992 on. One of the parameters to evaluate immunogenicity of a vaccine is durability of post-vaccine response that permits to prove whether a reinforcement dose is needed or not. Taking the importance of this type of study into account, the levels of antibodies to HBV (anti-HbsAg) were quantified in the children of a day-care center who were vaccinated as part of the National Immunization Program. These children were distributed by years of life: First year(I), 19 children; second year (II) 10; third year (III) 31; fourth year (IV) 24; and firth year (V) 22, totalling 106 children. The serological samples were assessed by ELISA in the Department of Immunology of the "Victoria de Girón" Institute of Basic and Pre-clinical Sciences. In each studied group, the number of children with seroprotection (10 UI/L or higher) and hyperesponse (100 UI/L or higher) were determined. Additionally, the arithmetic mean was calculated. The levels of seroprotection and hyperesponse were over 93 and 76% respectively. The arithmetic mean was over 181 UI/L in all the studied groups

Keywords : IMMUNIZATION; PROGRAMS; HEPATITIS B VACCINES [immunology]; VACCINES, SYNTHETIC HEPATITIS B SURFACE ANTIGENS [analysis]; MASS VACCINATION; CHILD DAY CARE CENTERS.

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