Abstract

ACOSTA, Tatiana et al. Efecto hemolítico de la cloroquina en estudiantes deficientes de glucosa-6-fosfato deshidrogenasa. Rev Cubana Invest Bioméd [online]. 2003, vol.22, n.3, pp. 180-185. ISSN 1561-3011.

The presence of students carriers of the deficiency in the glucose-6-phosphate erytrocitary dehydrogenase enzyme was studied at the "Victoria de Girón" Institute of Basic and Preclinical Sciences by using the methylene blue method, the enzymatic activity and the starch gel electrophoresis. Later, it was studied the hemolytic effect of the prophylactic administration of chloroquine phosphate to these subjects and the variations in the concentration of hemoglobin and hematocrit with clinical significance before and after the treatment with this drug. The existance of diseases associated with hemolytic pictures among individuals carriers of this disease was discarded. Of the 994 Latin American students attended at the Institute in 2001, 8 were confirmed as G6PD deficient. The treatment with chloroquine did not cause hemolysis.

Keywords : GLUCOSEPHOSPHATE DEHYDROGENASE; CHLOROQUINE [therapeutic use]; HEMOLYSIS; OXIDANTS; METHYLENE BLUE.