Abstract

RIVERON FORMENT, Gretel. Estrés oxidativo y ataxias hereditarias. Rev Cubana Invest Bioméd [online]. 2003, vol.22, n.3, pp. 199-203. ISSN 1561-3011.

The present health status of the heredodegenerative spinocerebellar diseases, which are a set of entities whose best defined nosological trait nowadays is their hereditary character, was reviewed. Hereditary ataxias, as they are commonly called, include a wide group of heterogenous syndromes from the clinical and genetical point of view, whose clinical basic sign is a variable disorder of the motor coordination, secondary to a primary spinocerebellar degeneration. Although the characteristics of these entities may be different, there are evidences that the free radicals and the oxidative stress may be involved in the neuronal death that appears as a general mechanism of cellular damage. The fundamental studies about the influence of the oxidative damages on the physiopathology of these heredodegenerative disorders have been conducted mainly in Friedrecich's ataxia, ataxia-telangiectasia and vitamin E-deficiency ataxia, since the events associated with them may somehow be explained by theories linking them directly or indirectly to the oxidative stress.

Keywords : OXIDATIVE STRESS; HEREDODEGENERATIVE DISORDERS; NERVOUS SYSTEM; ATAXIA; SPINOCEREBELLAR DEGENERATIONS.