Abstract

TRAVIESO GONZALEZ, Yelamy et al. Use of neurotrophic substances as therapeutics in retinitis pigmentosa. Rev Cubana Invest Bioméd [online]. 2005, vol.24, n.2, pp. 0-0. ISSN 1561-3011.

A review of the neurotrophic substances as therapeutics in retinitis pigmentosa, one the most studied retinal dystrophies, was made. It is a chronic and noncommunicable disease with great clinical and genetical heterogeneity that is characterized by the progressive loss of the photoreceptors, which leads to blindness. Its treatment is one the serious problems that have not been solved yet at the world level. There have been published scientific papers on new substances that may have a neuroprotective, angiogenic, and mitogenic effect on the nervous system, specifically on the cellular elements of the retina. These neurotrophic substances suggest a therapeutic alternative on the short term in the neurodegenerative diseases of the retina with great success and recovery of the visual function of the cells that have not died by the modulation of the apoptosis process in animal models with retinitis pigmentosa. It is expected that in a future they will be used combined with other techniques of larger scope as, for example, the genic therapy.

Keywords : Retinitis pigmentosa; retinal dystrophies; apoptosis; photoreceptors; neurotrophic substances.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )