Abstract

ADORNA CARMENATE, Zulema. Nonalcoholic esteatohepatitis: Physopathogeny and experimental models. Rev Cubana Invest Bioméd [online]. 2007, vol.26, n.1, pp. 0-0. ISSN 1561-3011.

A review of nonalcoholic esteatohepatitis, which was considered for many years a rare disease with good prognosis, was made. However, on knowing that between 15 and 50 % of these patients present fibrosis and even cirrhosis in their biopsies, that perception changed and nowadays it is one of the entities where the attention is focussed the most in the field of Hepatology. In spite of the fact that the pathogeny of this entity is complex and it has not been well elucidated yet, the theory of the 2 hits proposed in 1998 explains the main physiopathogenic mechanisms involved in its development. There are various experimental models for the study of nonalcoholic esteatohepatitis. Nevertheless, the animal model that reproduces the physiopathogeny of nonalcoholic esteatohepatitis with the highest fidelity is the one attained by Liber et al., starting from the use of a fat-rich liquid diet in rats.

Keywords : Nonalcoholic esteatohepatitis; physiopathogeny; experimental models.