Abstract

SANCHEZ PEREZ, Iraisa  and  NAVARRO FERNANDEZ, Raymundo. Protective effect of epidermal growth factor in Kanamycin-induced toxic nephritis  . Rev Cubana Invest Bioméd [online]. 2007, vol.26, n.2, pp. 0-0. ISSN 1561-3011.

The objective was to determine if epidermal growth factor with its regenerating and protective function, was capable of protecting kidneys from toxic effect of kanamycin. To this end, a prospective experimental research study on animals was designed. They were divided into three groups, one was administered antibiotic in a way similar to humans; the second group was given the antibiotic plus a prophylactic one-dose of the factor, and the third group was the negative control. At the beginning and at the end of the study, renal function was assessed and a histological study was performed on the three groups.  All the quantitative variables were statistically analyzed to find significance among the groups.  It was observed that the negative control and the group receiving the factor had a similar behaviour, but the group under antibiotic treatment behaved differently. The factor was a protector of proximal nephrone.

Keywords : Toxic nephritis; kanamycin; epidermal growth factor.