Abstract

DIAZ GARCIA, Carlos Manlio  and  ALVAREZ GONZALEZ, Julio L.. Physiological aspects of Zn cathion and its cardiovascular implications. Rev Cubana Invest Bioméd [online]. 2009, vol.28, n.2, pp. 0-0. ISSN 1561-3011.

Introduction Versatility of Zn^{+2 in the physiology of several cell types has led to growing attention by the scientific community on the functional roles and the regulation of this cation levels. Objectives To present a literature review on this topic, making emphasis on the cardiovascular implications of Zinc. Data source Pubmed from the Central Service of Biotechnological Information of the US National Institutes for Science (NCBI in English) from which 52 scientific articles were read. Results Cation Zinc is not only a co-factor for numerous enzymes (for example carbon anhydrase) and involved in several metabolic processes, but participates as modulator of synapses through its blocking action of various ion channels. This explains why, although the Zn deficiency may cause body physiology disorders, the excessive presence of this ion even locally could interfere in the electrical activity of excitable tissues such as the myocardium. Conclusions For these reasons, it is important to study the cardioprotective effects of Zinc, but at the same time, it is necessary to know the mechanisms and the doses through which it may have harmful impact.}

Keywords : Cation Zinc; cardiovascular effect of Zn⁺².